Embryonic aneuploidy does not differ among genetic ancestry according to continental origin as determined by ancestry informative markers
نویسندگان
چکیده
منابع مشابه
To what extent does genealogical ancestry imply genetic ancestry?
Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past [Chang, J.T., 1999. Recent common ancestors of all present-day individuals. Adv. Appl. Probab. 31, 1002-1026. 1027-1038; Rohde, D.L.T., Olson, S., Chang, J.T., 2004. Modelling the recent common ancestry of all living humans. Nature 431, 562-566]. Howe...
متن کاملGenomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease.
The β(s) mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the genetic structure of a population. In this study, we have estimated the g...
متن کاملAncestry informative marker sets for determining continental origin and admixture proportions in common populations in America.
To provide a resource for assessing continental ancestry in a wide variety of genetic studies, we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs). The markers were chosen for informativeness, genome-wide distribution, and genotype reproducibility on two platforms (TaqMan assays and Illumina arrays). We analyzed genotyping data from 825 subjects with div...
متن کاملCoAIMs: A Cost-Effective Panel of Ancestry Informative Markers for Determining Continental Origins
BACKGROUND Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations. Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies. Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an...
متن کاملInformation on ancestry from genetic markers.
It is possible to estimate the proportionate contributions of ancestral populations to admixed individuals or populations using genetic markers, but different loci and alleles vary considerably in the amount of information that they provide. Conventionally, the allele frequency difference between parental populations (delta) has been used as the criterion to select informative markers. However,...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2016
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dew195